Search results for "lung inflation"

showing 9 items of 9 documents

Deep inspiration-induced changes in lung volume decrease with severity of asthma

2007

Summary We have previously reported that the magnitude of deep inspiration (DI)-induced bronchodilation is only slightly reduced in mild asthmatics, compared to healthy subjects. The aim of this study was to evaluate whether increased severity of asthma is associated with impairment in the ability of DI to induce changes in lung volume. Thirty-six consecutive asthmatics recruited from the Pulmonary and the Allergy Outpatient Clinics of the Institute of Respiratory Diseases of the University of Palermo were divided into 3 groups: Intermittent (I), Mild Persistent (MP) and Moderate–Severe (MS), based on GINA guidelines. Single dose methacholine (Mch) bronchoprovocations were performed in the …

AdultMalePulmonary and Respiratory MedicineAllergymedicine.medical_specialtyAdolescentVital CapacityBronchiSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologySeverity of Illness IndexBronchial Provocation TestsDrug Administration ScheduleLung inflationBronchoconstrictor Agents03 medical and health sciencesFEV1/FVC ratio0302 clinical medicineInternal medicineForced Expiratory VolumemedicineOutpatient clinicCorticosteroidsHumansLung volumesAlbuterol030212 general & internal medicineasthma deep inspiration lung functionMethacholine ChlorideAsthmaAgedMethacholinebusiness.industryRespiratory diseaseMiddle Agedmedicine.diseaseAsthma3. Good healthBronchodilator Agents030228 respiratory systemInhalationAnesthesiaSalbutamolMethacholineBronchodilationFemalebusinessmedicine.drugRespiratory Medicine
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Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: Study protocol for a pilot randomized controlled trial, the PROT…

2018

Background Adding cyclic short sustained inflations (sigh) to assisted ventilation yields optimizes lung recruitment, decreases heterogeneity and reduces inspiratory effort in patients with acute hypoxemic respiratory failure (AHRF). These findings suggest that adding sigh to pressure support ventilation (PSV) might decrease the risk of lung injury, shorten weaning and improve clinical outcomes. Thus, we conceived a pilot trial to test the feasibility of adding sigh to PSV (the PROTECTION study). Methods PROTECTION is an international randomized controlled trial that will be conducted in 23 intensive care units (ICUs). Patients with AHRF who have been intubated from 24 h to 7 days and under…

procedurePressure supportTime Factorsgenetic structuresbreathingmedicine.medical_treatmentMedicine (miscellaneous)Pilot Projects[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractintensive care unitlaw.inventionPositive-Pressure RespirationStudy Protocol0302 clinical medicineMechanical ventilationRandomized controlled triallawtime factorClinical endpointpatient safetyMulticenter Studies as TopicPharmacology (medical)030212 general & internal medicinerandomized controlled trial (topic)Intervention study; Mechanical ventilation; Positive-pressure ventilation; Pressure support; Recruitment; Sigh; Ventilator-induced lung injury; Weaning; Feasibility Studies; Humans; Hypoxia; Intubation Intratracheal; Lung; Multicenter Studies as Topic; Pilot Projects; Positive-Pressure Respiration; Recovery of Function; Respiratory Insufficiency; Time Factors; Treatment Outcome; Randomized Controlled Trials as Topic; Medicine (miscellaneous); Pharmacology (medical)HypoxiaLungpathophysiologyendotracheal intubationRandomized Controlled Trials as TopicVentilator-induced lung injurylcsh:R5-920Intervention studyadultpilot studyfeasibility studytreatment outcome Feasibility Studie3. Good healthTreatment OutcomeAnesthesiapositive end expiratory pressureBreathingmulticenter study (topic)oxygenationRecruitmentlcsh:Medicine (General)Respiratory Insufficiencyrespiratory tract intubationcirculatory and respiratory physiologyHumanextubationPressure support ventilationWeaningLung injuryArticleSpontaneous breathing trialNO03 medical and health sciencesIntensive care[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]medicineIntubation IntratrachealHumanscontrolled studyPilot ProjectSightreatment failureMechanical ventilationhypoxemiapressure support ventilationtreatment durationbusiness.industrylung inflationrespiratory failureconvalescenceRecovery of Functionmajor clinical studymortalitywater acute respiratory failurehospital dischargeIntratracheal030228 respiratory systemrandomized controlled trialFeasibility StudiesbusinessPositive-pressure ventilationIntubationclinical protocol
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Alterations of the beneficial effect of deep inspiration in scleroderma: relationships between lung function and imaging.

2007

<i>Background:</i> It has been postulated that the beneficial effects of deep inspiration are dependent on the magnitude of airway distension by virtue of airway to parenchyma interdependence. <i>Objective:</i> This study was designed to examine whether the changes that occur in pulmonary fibrosis affect the beneficial effect of deep inspiration. <i>Methods:</i> Thirty-one subjects with scleroderma underwent lung volume and diffusion capacity assessment as well as high-resolution computed tomography. To assess the effect of deep inspiration, each subject underwent methacholine provocations in the absence of deep breaths. When the targeted change in lung f…

MalePulmonary and Respiratory MedicinePathologymedicine.medical_specialtyPulmonary FibrosisVital CapacityDistensionSettore MED/10 - Malattie Dell'Apparato RespiratorioBronchial Provocation TestsSclerodermaBronchoconstrictor AgentsScleroderma LocalizedForced Expiratory VolumeParenchymamedicineHumansLungMethacholine ChlorideBronchusLungbusiness.industryRespiratory diseaseInterstitial lung diseaseMiddle Agedrespiratory systemmedicine.diseaserespiratory tract diseasesmedicine.anatomical_structureInhalationRespiratory Mechanicsconnettive diseases lung inflation imagingFemaleTomography X-Ray ComputedAirwaybusiness
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The loss of the beneficial effect of deep inspiration (DI) in COPD is associated with severity of disease

2007

lung inflation methacholine bronchial obstructionSettore MED/10 - Malattie Dell'Apparato Respiratorio
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Inspiration through the nose increases the bronchoprotective effect of lung inflation

2007

medicine.medical_specialtybusiness.industryVital CapacityImmunologyBronchiNoseSettore MED/10 - Malattie Dell'Apparato Respiratoriodeep inspiration asthma lung functionmedicine.anatomical_structureInhalationForced Expiratory VolumeInternal medicineCardiologymedicineHumansImmunology and AllergyLung inflationbusinessLungNose
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Inhaled Corticosteroids and the Beneficial Effect of Deep Inspiration in Asthma

2005

Deep inspiration-induced bronchoprotection and bronchodilation are impaired in asthma. We evaluated the effect of inhaled glucocorticosteroids on these phenomena. Two groups of subjects with asthma, 9 with moderate/severe hyperresponsiveness to methacholine, and 12 with mild/borderline hyperresponsiveness to methacholine, received inhaled fluticasone (880 microg daily) for 12 weeks. Serial bronchoprovocations were performed at Weeks 0, 6, and 12. The impact of deep inspirations on the airway response to methacholine was evaluated on the basis of inspiratory vital capacity and FEV(1). Fluticasone produced a wide spectrum of changes in the beneficial effects of deep inspiration, but the mean …

AdultMalePulmonary and Respiratory MedicineRespiratory Therapymedicine.drug_classVital CapacityRespiratory physiologySettore MED/10 - Malattie Dell'Apparato RespiratorioCritical Care and Intensive Care MedicineSeverity of Illness IndexBronchial Provocation TestsBronchoconstrictor AgentsForced Expiratory VolumeIntensive careAdministration Inhalationlung inflation asthma treatmentBronchodilationmedicineHumansMethacholine ChlorideAgedFluticasoneAsthmaInhalationbusiness.industryMiddle Agedmedicine.diseaseAsthmaBronchodilator AgentsA. Asthma and Allergyrespiratory tract diseasesAndrostadienesInhalationAnesthesiaRespiratory MechanicsFluticasoneCorticosteroidFemaleMethacholineBronchial Hyperreactivitybusinessmedicine.drugAmerican Journal of Respiratory and Critical Care Medicine
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Airway Distensibility by HRCT in COPD Patients

2006

lung inflation bronchial obstruction methacholineSettore MED/10 - Malattie Dell'Apparato Respiratorio
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Association between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments.

2005

Abstract Background We have previously shown that the bronchodilatory effect of deep inspiration is attenuated in individuals with COPD. This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments. Methods We measured deep inspiration (DI)-induced bronchodilation in 15 individuals with and without COPD (67 ± 2.2 yrs of age, mean ± SEM) undergoing lobar resection for peripheral pulmonary nodule. Prior to surgery, we measured TLCO and determined the bronchodilatory effect of deep inspiration after constricting the airways with methacholine. The number of destroyed alveolar attachments, as well as airway wall area and airway smoo…

Pulmonary and Respiratory MedicineMalemedicine.medical_specialtyPathologyStatistics as TopicBronchial provocation testsCOPD lung inflationBronchi030204 cardiovascular system & hematologySettore MED/10 - Malattie Dell'Apparato RespiratorioBronchial Provocation Tests03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineInternal medicinemedicineHumansLung volumesMethacholine ChlorideAgedlcsh:RC705-779COPDbusiness.industryResearchAirway smooth musclelcsh:Diseases of the respiratory systemrespiratory systemmedicine.diseaserespiratory tract diseasesPulmonary Alveoli030228 respiratory systemMethacholine chlorideInhalationAirway wallCardiologyMethacholineFemalebusinessmedicine.drugRespiratory research
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Lung hyperinflation in COPD attenuates airway distension by deep inspiration (DI) measured with HRCT

2005

imaging lung inflationSettore MED/10 - Malattie Dell'Apparato Respiratorio
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